Editorial

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Numerical and experimental investigation of leaks in viscoelastic pressurized pipe flow

Abstract. This paper extends the analysis concerning the importance in numerical models of unsteady friction and viscoelasticity to transients in plastic pipes with an external flow due to a leak. In fact recently such a benchmarking analysis has been executed for the cases of a constant diameter pipe (Duan et al., 2010), a pipe with a partially closed in-line valve (Meniconi et al., 2012a), and a pipe with cross-section changes in series (Meniconi et al., 2012b). Tests are based on laboratory experiments carried out at the Water Engineering Laboratory (WEL) of the University of Perugia, Italy, and the use of different numerical models. The results show that it is crucial to take into account the viscoelasticity to simulate the main characteristics of the examined transients

Preface: CCWI 2013

Since 1991 "Computing and Control for the Water Industry – CCWI" is a well-established series of bi-annual meetings. On 2–4 September 2013, the 12th edition (CCWI2013) was held in Perugia (Italy) and was focused on Information for Water Systems and Smart Cities. CCWI2013 emphasized the integration between the more conventional themes of the analysis and planning of water systems and information technology. Such an integration offers opportunities for design solutions and innovative models for the challenging problems of water system management in an urban perspective, a key concept for smart cities (Brunone and Giustolisi, 2014). The large number of presentations – more than 200 with many young researchers from Europe and overseas – confirmed the interest for CCWI2013 themes and the increasing success of CCWI Conferences (Fig. 1). This CCWI2013 special issue contains a selection of extended CCWI2013 papers which give a taste of the Proceedings of the Conference published on Procedia Engineering Elsevier (www.sciencedirect.com/science/journal/ 18777058/70). In fact their topics range from sustainabilitybased indicators of the urban water systems (Behzadian et al., 2014), design and control parameters in water treatment (Ramphal and Sibiya, 2014), numerical simulation of the transition between surface and pressurized flow (Fernandez-Pato and Garcia-Navarro, 2014) to optimisation of pump and valve schedules in complex large-scale water distribution networks (Skworcow et al., 2014), and a real data-based model to simulate the behavior of a pumping station equipped with variable speed pumps (Capponi et al., 2014). Figure 1. Last nine editions of CCWI conferences: number of papers published in the proceedings (from Brunone and Giustolisi, 2014)

Advanced Hydroinformatic Techniques for the Simulation and Analysis of Water Supply and Distribution Systems

[EN] This document is intended to be a presentation of the Special Issue "Advanced Hydroinformatic Techniques for the Simulation and Analysis of Water Supply and Distribution Systems". The final aim of this Special Issue is to propose a suitable framework supporting insightful hydraulic mechanisms to aid the decision-making processes of water utility managers and practitioners. Its 18 peer-reviewed articles present as varied topics as: water distribution system design, optimization of network performance assessment, monitoring and diagnosis of pressure pipe systems, optimal water quality management, and modelling and forecasting water demand. Overall, these articles explore new research avenues on urban hydraulics and hydroinformatics, showing to be of great value for both Academia and those water utility stakeholders.Herrera Fernández, AM.; Meniconi, S.; Alvisi, S.; Izquierdo Sebastián, J. (2018). Advanced Hydroinformatic Techniques for the Simulation and Analysis of Water Supply and Distribution Systems. Water. 10(4):1-7. https://doi.org/10.3390/w10040440S1710

Transient Effects of Self-adjustment of Pressure Reducing Valves

AbstractPressure control strategy through Pressure Reducing Valves (PRV) has been deeply investigated as management strategy, aimed at water leakages reduction avoiding very expensive pipe replacement programs. On the contrary, few experimental data are available in literature, with regard to PRV transient behavior in terms of its response to incoming pressure waves, as well as the time required for achieving the pressure set point. In this paper, the results of some experimental tests are presented. The PRV is installed in a single high density polyethylene pipe and transients are generated by operating the downstream end valve. Two types of tests are considered: a partial valve closure and opening simulating a water demand decrease and increase, respectively. The analysis of the experimental pressure traces points out the valuable effects of the PRV on transient characteristics with respect to the case of a partially closed in-line valve with a constant opening degree

Functioning conditions of the Casale pumping station in Mantova, Italy

Abstract. Pump speed, input power, pressure and discharge data are analyzed for evaluating functioning conditions of Casale pumping station in Mantova, Italy, managed by TeaAcque. A model based on the affinity laws is used to simulate the behavior of the installed variable speed pumps. Quadratic and cubic polynomial curves are used to fit the pump data given by the affinity laws. Such curves allow predicting the efficiency when the functioning conditions change. The relationship between the rotation speed and the efficiency is also derived

Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.

The PARP enzyme and scaffolding protein tankyrase (TNKS, TNKS2) uses its ankyrin repeat clusters (ARCs) to bind a wide range of proteins and thereby controls diverse cellular functions. A number of these are implicated in cancer-relevant processes, including Wnt/β-catenin signalling, Hippo signalling and telomere maintenance. The ARCs recognise a conserved tankyrase-binding peptide motif (TBM). All currently available tankyrase inhibitors target the catalytic domain and inhibit tankyrase's poly(ADP-ribosyl)ation function. However, there is emerging evidence that catalysis-independent "scaffolding" mechanisms contribute to tankyrase function. Here we report a fragment-based screening programme against tankyrase ARC domains, using a combination of biophysical assays, including differential scanning fluorimetry (DSF) and nuclear magnetic resonance (NMR) spectroscopy. We identify fragment molecules that will serve as starting points for the development of tankyrase substrate binding antagonists. Such compounds will enable probing the scaffolding functions of tankyrase, and may, in the future, provide potential alternative therapeutic approaches to inhibiting tankyrase activity in cancer and other conditions

Real Data Analysis and Efficiency of the TEA Mantova Casale (Italy) Variable-speed Pumping Station

AbstractVariable speed pumps (VSPs) are widely used in water distribution systems (WDSs). They can increase the efficiency of the system and reduce the energy consumptions, when the functioning conditions move away from those used for the design. Affinity laws allow to model the characteristic curve of VSPs, in terms of dimensionless flow, head and power. Efficiency of the VSPs can also be predicted, although the effects of the variation in the rotation speed can be questioned. In this paper, the experimental data acquired by TeaAcque at the Mantova Casale pumping station are interpreted by means of the dimensionless equations derived by the affinity laws. The measured “wire to water” efficiency of the system is compared to the theoretical one

Further developments in rapidly decelerating turbulent pipe flow modeling

2013-2014 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe